vicissitudes

/vɪˈsɪsɪtuːd/

vi·cis·si·tude

BrE /vɪˈsɪsɪtjuːd/

NAmE /vɪˈsɪsɪtuːd/

[usually pl.] (formal)

one of the many changes and problems in a situation or in your life, that you have to deal with