/ˈwɪrinəs/
noun
great tiredness:
She knew she should keep running, but intense fatigue and weariness overtook her.
30 hours or more of intense physical training might induce some stress or weariness.

the state of being bored with something because you have experienced too much of it:
I must admit a certain weariness when reading those passages.
As soon as they began to talk, he shut his eyes and expressed weariness and indifference.

adjective
very tired, especially after you have been working hard or doing sth for a long time (尤指长时间努力工作后)疲劳的,疲倦的,疲惫的
a weary traveller
疲惫不堪的旅行者
She suddenly felt old and weary.
她突然感到了衰老和疲倦。
a weary sigh
疲倦的叹息