1. 使发怒;使回忆起来;使侃侃而谈;If something sets a person off, it makes them angry, or makes them remember something and they start talking a lot.
    The smallest thing sets him off, and he can’t stop talking about his childhood.
    一件微不足道的小事都能打开他的话匣子,他会滔滔不绝地讲述他的童年。

  2. to make sth more noticeable or attractive by being placed near it 衬托;使显得更突出(或更漂亮)
    That blouse sets off the blue of her eyes.
    那件上衣衬托出了她的蓝眼睛。

  3. to begin a journey
    We set off for London just after ten.