to disagree with or object to sth 对…有异议；不同意；反对
I have no problem with you working at home tomorrow.
你明天在家里工作，我没有意见。
informal
We are going to do this my way. Do you have a problem with that? (= showing that you are impatient with the person that you are speaking to)
这件事将按照我的方法来做，你有什么意见吗？