~ sb/sth/yourselfto destroy sb/sth completely 消灭；歼灭；毁灭
The human race has enough weapons to annihilate itself.
人类有足够的武器灭绝自己。
~ sb/sthto defeat sb/sth completely 彻底击败
She annihilated her opponent, who failed to win a single game.
她大获全胜，对方连一局也没有赢。